Web1 jan. 2013 · Mitotane [1- (2-chlorophenyl)-1- (4-chlorophenyl)-2,2-dichloroethane] is the first-line treatment for metastatic adrenocortical carcinoma (ACC) and is also regularly used in the adjuvant setting after presumed complete removal of the primary tumor. Web1 mei 2024 · Patients who did not receive the alternative second-line therapy had better overall survival with first-line EDP plus mitotane (17.1 month) than with streptozocin plus mitotane (4.7 months).
Central Hypothyroidism is Frequent During Mitotane Therapy in ...
WebWhen the mitotane concentrations reached the therapeutic range (defined as mitotane plasma levels between 14-20 microg/mL), a dose reduction was performed to avoid … Web1 mei 2024 · We associate adjuvant mitotane with local radiotherapy, limiting the combined therapy in. Selection of patients to adjuvant mitotane. Despite the limits of the available evidence, adjuvant mitotane therapy is currently recommended in many expert centers whenever the patients present an elevated risk of recurrence (Fig. 1). the macallan fine oak
Mitotane - Wikipedia
Web29 aug. 2024 · Robinson BG, Hales IB, Henniker AJ, et al. The effect of o,p'-DDD on adrenal steroid replacement therapy requirements. Clin Endocrinol (Oxf) 1987; 27:437. Kamenický P, Droumaguet C, Salenave S, et al. Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent … Web1 sep. 2011 · Mitotane is highly effective in the long-term management of Cushing's syndrome but has a slow onset of action. Mitotane combined with fast-acting … Web12 aug. 2024 · Mitotane oder ortho-para-DDD (Handelsname in Europa: Lysodren®, HRA-Pharma, Paris, Frankreich) ist ein Orphan-Arzneimittel zur adjuvanten Therapie des … the macallan fine oak 15