Irf7 function
WebMay 4, 2015 · Ciancanelli et al. (2015) concluded that IRF7 deficiency disrupts the main function of plasmacytoid dendritic cells that produce antiviral interferons. The patient …
Irf7 function
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WebThe observed association might be attributable to its close proximity with interferon regulatory factor 7 ( IRF7 ), because the strong LD ( r2 = 0.94) between this disease-associated SNP and a 3′ UTR PHRF1 SNP (rs702966) is within 0.6-kb flanking region of the IRF7 gene (51). IRF7, similar to IRF5, is a transcription factor that can activate ... WebIRF7 plays a major role in the amplification of IFNα production downstream of PRR activation; in most cell types IRF7 is induced by innate IFN priming, however, it is also constitutively expressed in plasmacytoid DCs, where it drives the rapid synthesis of large quantities of IFNα subtypes in response to toll-like receptor (TLR) activation.
WebMar 21, 2024 · Molecular function for IRF7 Gene according to UniProtKB/Swiss-Prot In the absence of viral infection, maintained as a monomer in an autoinhibited state and … WebApr 4, 2024 · IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta-mediated NK activity. The MYC is shown to be recruited to the IRF7 promoter region …
WebNov 3, 2024 · IRF7 is considered more important in amplification of an antiviral response, post-induction ( Sharma et al., 2003 ). IRFs Are Highly Expressed across Bat Tissues In Vivo To validate expression, IRF1 mRNA levels were examined using a cDNA panel generated from 10 tissues isolated from 3 bats/mice ( Figure 2 A). WebSep 6, 2024 · Previously, we found that IRF3 and IRF7 could mediate the acquisition of new anti-tumor effector functions in macrophages . In the present study, we observed that high IRF3 and IRF7 expression was related to CD4 + T cell, CD8 + T cell, B-cell, and macrophage activation, indicating that IRF3 and IRF7 could promote the anticancer effect of immune ...
WebJan 8, 2024 · IRF7 on the other hand, is a lymphoid transcription factor constitutively expressed only in B cells, monocytes and plasmacytoid dendritic cells (pDC)s . pDCs in particular express high levels of IRF7, while in most other cell types IRF7 is inducible from low levels of expression . Thus, early during infection IRF7 only has a minor contribution ...
WebConstitutive IRF7 expression allows pDCs to rapidly produce large amounts of type I IFN in response to viruses, making them a professional type I IFN–producing cell type thataccountsformostcirculatingtypeIIFNduringanantiviralinnate immune response (2, 3). pDCsareactivated followingthesensingofviral RNA orDNAby TLR7 and TLR9, respectively. can i throw away a monitorWebJul 4, 2013 · This is in contrast to murine IRF7, which acts as a master regulator of type I IFN production upon TLR7 and TLR9 stimulation in murine cells 22. Further studies will be needed to clarify the function of human IRF7 in type I IFN production in different human cell populations and how human IRF7 is involved in late type I IFN induction. five nights at freddy\\u0027s 2 rewritten 87WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. can i throw away a humidifierWebNov 30, 2024 · IRF7 is a member of IRF family and was originally identified in the Epstein-Barr virus (EBV) infection. 13 And it is an essential regulator of type IFNs via triggering signaling cascades from pathogen recognition receptors (PRRs) that recognizing nucleic acids from pathogenes. 13 IRF7 has pivotal roles during antiviral immune responses and … can i throw away a mattressWebMar 29, 2024 · A non-synonymous SNP in IRF 7 is associated with enhanced IRF7 activity and is associated with SLE ( 48 ). A role for IRF8 in stabilizing the basal transcription … five nights at freddy\u0027s 2 revisitedWebJun 7, 2024 · IRF7 silencing reverts mitochondrial gene expression and function. (A) IRF7 was knocked down in 12-month-old (12mo) MSCs using shRNA (shIRF7). Knockdown of IRF7 expression was assessed by western blotting (WB) and qPCR, as compared to expression in cells transformed with empty vector or control scrambled shRNA. Blot is … can i throw away a refrigeratorWebApr 11, 2024 · Conclusion Six potential candidate genes (SFN, KDM5B, MYLK, IRF3, IRF7, and ID1) had been identified, all of which had diagnostic significance. ... In addition to the biological functions ... can i throw away a laptop