Cisplatin pulmonary fibrosis

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August undefined, 2024

WebOct 15, 2024 · Cisplatin forms intrastrand crosslinks in DNA, which disturbs DNA replication and causes DNA damage, eventually inducing necrosis or apoptosis. Cisplatin-based chemotherapy is widely used to... WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can lead to …

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WebSep 1, 2024 · Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP contains 50 mg Cisplatin, 450 mg Sodium Chloride, USP, and 500 mg Mannitol, USP. Cisplatin for Injection, USP may contain hydrochloric acid for pH adjustment. WebThe fibrosis consisted of mildly inflamed, densely scarred tissue with thin dilated vessels, and was present to a significant extent that is suggestive of spontaneous regression. ... etoposide and cisplatin), which were completed in 80 days. There was no evidence of disease in 3.4 years of post-operative follow-up with serum and imaging studies ... high liner english style fish

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WebMar 6, 2024 · Pulmonary fibrosis is a chronic, progressive disease, meaning it worsens over time. Learning more about the disease can help you and your family cope. Attending pulmonary rehabilitation can help you manage your symptoms and improve your daily functioning. Having pulmonary fibrosis can cause fear and stress. WebAbstract. Combination chemotherapy that included bleomycin and cisplatin was administered to 45 evaluable patients (30 with cervix carcinoma and 15 with germ cell … WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary … high liner foods head office

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WebPulmonary fibrosis (PF) is part of a larger group of more than 200 interstitial lung diseases (also known as ILDs) that are characterized by inflammation and/or scarring in the lung. In ILDs, the injury and damage … WebFeb 2, 2024 · Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application ... Protective Effects of GHK-Cu in Bleomycin-Induced Pulmonary Fibrosis via Anti-oxidative Stress and Anti-inflammation Pathways. high liner foods headquartersWebFeb 22, 2016 · In patients treated for disseminated testicular cancer with bleomycin, etoposide, and cisplatin (BEP), the risk of acute bleomycin-induced changes is ≤ 6.8%, with a 0% to 1% risk of death. 1 - 4 Serious long-term toxicity has been indicated with an increased risk of late mortality caused by pulmonary diseases. 5 These findings were … high liner foods products

"WebMar 12, 2024 · Interstitial inflammation, fibrosis, structural pulmonary damage, and other severe complications have also been reported during cisplatin chemotherapy [ 5 ]. These adverse effects of cisplatin-induced … " - Cisplatin pulmonary fibrosis

Cisplatin pulmonary fibrosis

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WebSep 18, 2024 · NCBI Bookshelf WebNov 26, 2024 · Ginkgolic C17:1 or cisplatin alone inhibited the PI3K/AKT/mTOR pathway in hepatoblastoma HepG2 cells, and co-treatment exhibited an enhanced inhibitory effect, while in normal hepatocytes, ginkgolic C17:1 alone did not significantly impact this signaling pathway, rather reducing cisplatin-caused inhibition to prevent cell damage [ 43 ].

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WebSep 8, 2024 · Interstitial lung disease (ILD) is a disease with progressive deterioration of respiratory function ( 1 ). ILD is an independent risk factor for lung cancer (LC). Among patients diagnosed with lung cancer, 5.8–15.2% of patients have ILD ( 2, 3 ). WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台

WebSome of the more common medication types that are known to carry the risk of pulmonary fibrosis include certain: antibiotics, particularly nitrofurantoin immunosuppressant drugs, such as methotrexate drugs for heart conditions, particularly amiodarone cancer chemotherapy drugs biological agents used to treat cancer or immune disorders. WebAug 7, 2024 · Its potent anti-inflammatory and anti-fibrotic effects were demonstrated in animal models of lung fibrosis including bleomycin-induced lung injury and fibrosis. Oku et al. showed that both prophylactic and therapeutic administration of pirfenidone attenuated lung fibrosis induced by intravenous bleomycin in mice [ 5 ].

WebAbstract. Idiopathic pulmonary fibrosis (IPF) is a deadly and progressive fibrotic lung disease, but the precise etiology remains elusive. IPF is characterized by the presence … WebMar 20, 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with an undefined etiology and poor prognosis. The prevalence of lung cancer is much higher in IPF patients than in the general population, and lung cancer significantly worsens the prognosis of IPF [ 1 ].

WebMar 6, 2024 · Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue makes it more difficult for your lungs to work properly. As pulmonary fibrosis …

WebJul 3, 2024 · Pirfenidone is an anti-fibrotic drug used in the treatment of idiopathic pulmonary fibrosis and has also anti-proliferative activities. Mesothelioma cell proliferation was decreased by pirfenidone alone or in combination with cisplatin. Pirfenidone also decreased significantly Transwell migration/invasion and 3D collagen invasion. high liner foods new hampshireWebThe administration of aerosol bronchodilators and corticosteroids are used by several patients with respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, bronchiectasis, and lung infection [32,33,34]. Bronchodilators are known to dilate the airways that are narrowed due to the underlying ... high liner foods revenueWebFeb 24, 2024 · Certain chemotherapy medications, such as cisplatin, can cause damage to the kidneys and bladder. This can result in a decreased ability of your kidneys to filter your blood. Damage to the bladder can also occur and may be temporary or permanent. Symptoms of bladder irritation may include pain or urgency with urination, or blood in … high liner foods newsWebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, high liner foods stock splitWebThe clinical and histopathological data as well as the lack of an infectious cause indicate that pulmonary fibrosis was induced by oxaliplatin and 5-FU/folinic acid. Conclusion: This case demonstrates that treatment with oxaliplatin and 5-FU/folinic acid can cause acute pulmonary fibrosis. high liner foods sustainabilityWebBackground: Gemcitabine is the only approved cytotoxic agent for the treatment of pancreatic cancer by the Food and Drug Administration. In addition, gemcitabine is also commonly used for the management of breast, ovarian, and non-small cell lung cancer. Myelosuppression is the most common toxicity of gemcitabine therapy. high liner foods nova scotiaWebCisplatin and Pulmonary fibrosis, a phase IV clinical study of FDA data - eHealthMe. Pulmonary fibrosis is found among people who take Cisplatin, especially for people who … high liner foods usa incorporated