WebMolecular Function: chloramphenicol O-acetyltransferase activity Source:UniProtKB-EC. Biological Process: response to antibiotic Source:UniProtKB-KW. Expand table. … WebAmpicillin is one of the most commonly used extended-spectrum beta-lactams, and it is composed of a thiazolidine ring and side chain that is linked to the beta-lactam …
Chloramphenicol: Structure and Mechanism of Action
WebChloramphenicol peptides were recently established as useful tools for probing nascent polypeptide chain interaction with the ribosome, either biochemically, or structurally. … Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. ... Plasma levels of chloramphenicol must be monitored in neonates and patients with abnormal liver function. Plasma levels should be monitored in all children under the age of four, the elderly, ... See more Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various generic names in eastern Europe and Russia, including chlornitromycin, levomycetin, and chloromycetin; the … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis. In 1972, Senator See more changing gears on automatic truck
UniProt
Web722 rows · Chloramphenicol is a broad spectrum antibiotic that is effective against a … WebMacrolides, lincosamides, tetracyclines and chloramphenicol are structurally unrelated antibiotics which share protein synthesis inhibition as their common mechanism of action. Despite their individual differences, they can all be considered broad spectrum antibiotics with practical use for a wide variety of infections. WebNowadays, chloramphenicol is most often used intravenously, and since it readily crosses the blood-brain barrier, it may be used to treat bacterial meningitis in clients who have major hypersensitivity reactions to penicillin. changing gears on a motorcycle